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Sequencing, molecular profiling, and informatics have become established tools to develop drugs. More recently, these tools have been applied to profile patients for precision medicine indications. Historically, clinicians have been creating patient profiles from laboratory results and other clinical data. These data are being logged in Electronic Medical/Health Records. Efforts are currently underway to connect these laboratory and clinical data for use in translational research. The totality of these datasets (e.g., molecular, clinical, patient history and genealogy) comprise a “Clinical Infome.” Informed by these data, drug developers and physicians are better positioned to develop precision medicines.
Clinical Infomics entails the analysis of a patient’s profile in the context of relevant sample populations; these populations, in turn, are derived from databases of diverse populations and longitudinal studies. Design, development, curation, and maintenance of these databases is critical for assessing patients and making actionable decisions. Healthcare Associations and other organizations have reported efforts to create patient clinical infomes (e.g., Geisinger), however, few countries have invested in a nationwide clinical informatics project. Is there a path to comprehensive, shareable profiles for patients? Can these data be readily leveraged to develop innovative precision therapeutics? One can readily identify roadblocks to shareable patient records but the benefits to overcome roadblocks are considerable. We cover these questions and related themes at this Forum.
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Sequencing and Profiling to empower Precision Medicine